Delivering minocycline into brain endothelial cells with liposome-based technology

Minocycline has been proposed as a way to blunt neurovascular injury from matrix metalloproteinases (MMPs) during stroke. However, recent clinical trials suggest that high levels of minocycline may have deleterious side-effects. Here, we showed that very high minocycline concentrations damage endoth...

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Detalhes bibliográficos
Main Authors: Xing, Changhong, Levchenko, Tatyana, Guo, Shuzhen, Stins, Monique, Torchilin, Vladimir P, Lo, Eng H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367232/
https://ncbi.nlm.nih.gov/pubmed/22491155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.48
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