A tunable zinc finger-based framework for Boolean logic computation in mammalian cells

The ability to perform molecular-level computation in mammalian cells has the potential to enable a new wave of sophisticated cell-based therapies and diagnostics. To this end, we developed a Boolean logic framework utilizing artificial Cys(2)–His(2) zinc finger transcription factors (ZF-TFs) as com...

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Main Authors: Lohmueller, Jason J., Armel, Thomas Z., Silver, Pamela A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Synthetic Biology and Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367183/
https://ncbi.nlm.nih.gov/pubmed/22323524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks142
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