Ca(2+) improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination

Human RAD51 protein (HsRad51) catalyses the DNA strand exchange reaction for homologous recombination. To clarify the molecular mechanism of the reaction in vitro being more effective in the presence of Ca(2+) than of Mg(2+), we have investigated the effect of these ions on the structure of HsRad51...

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Main Authors: Fornander, Louise H., Frykholm, Karolin, Reymer, Anna, Renodon-Cornière, Axelle, Takahashi, Masayuki, Nordén, Bengt
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367181/
https://ncbi.nlm.nih.gov/pubmed/22362735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks140
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