Formation of Trans-Activation Competent HIV-1 Rev:RRE Complexes Requires the Recruitment of Multiple Protein Activation Domains

The HIV-1 Rev trans-activator is a nucleocytoplasmic shuttle protein that is essential for virus replication. Rev directly binds to unspliced and incompletely spliced viral RNA via the cis-acting Rev Response Element (RRE) sequence. Subsequently, Rev oligomerizes cooperatively and interacts with the...

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Detalhes bibliográficos
Main Authors: Hoffmann, Dirk, Schwarck, Doreen, Banning, Carina, Brenner, Matthias, Mariyanna, Lakshmikanth, Krepstakies, Marcel, Schindler, Michael, Millar, David P., Hauber, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366918/
https://ncbi.nlm.nih.gov/pubmed/22675540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038305
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