Leukotoxin (Leukothera®) Targets Active Leukocyte Function Antigen-1 (LFA-1) Protein and Triggers a Lysosomal Mediated Cell Death Pathway

Leukotoxin (LtxA) is a protein toxin that is secreted from the oral bacterium, Aggregatibacter actinomycetemcomitans. LtxA targets specifically the β(2) integrin, leukocyte function antigen-1 (LFA-1) on white blood cells (WBCs) and causes cell death. LtxA preferentially targets activated WBCs and is...

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Bibliographic Details
Main Authors: DiFranco, Kristina M., Gupta, Anukriti, Galusha, Lindsey E., Perez, Jarelys, Nguyen, To-Vy K., Fineza, Camille D., Kachlany, Scott C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366813/
https://ncbi.nlm.nih.gov/pubmed/22467872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314674
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