LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes*

Leukotoxin (LtxA) is a protein secreted from the oral bacterium Aggregatibacter actinomycetemcomitans. LtxA binds to the β(2) integrin lymphocyte-associated function antigen-1 (LFA-1) on human white blood cells (WBCs), resulting in cell death. LtxA is currently under investigation as a novel therapy...

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Publicado no:Leuk Res
Main Authors: DiFranco, Kristina M., Johnson-Farley, Nadine, Bertino, Joseph R., Elson, David, Vega, Brian A., Belinka, Benjamin A., Kachlany, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553223/
https://ncbi.nlm.nih.gov/pubmed/25850729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.03.010
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