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Prostaglandin EP(1) Receptor Down-regulates Expression of Cyclooxygenase-2 by Facilitating Its Proteasomal Degradation
The enzyme cyclooxygenase-2 (COX-2) is rapidly and transiently up-regulated by a large variety of signals and implicated in pathologies such as inflammation and tumorigenesis. Although many signals cause COX-2 up-regulation, much less is known about mechanisms that actively down-regulate its express...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366802/ https://ncbi.nlm.nih.gov/pubmed/22474323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304220 |
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