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Prostaglandin EP(1) Receptor Down-regulates Expression of Cyclooxygenase-2 by Facilitating Its Proteasomal Degradation

The enzyme cyclooxygenase-2 (COX-2) is rapidly and transiently up-regulated by a large variety of signals and implicated in pathologies such as inflammation and tumorigenesis. Although many signals cause COX-2 up-regulation, much less is known about mechanisms that actively down-regulate its express...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Haddad, Ariz, Flint-Ashtamker, Galit, Minzel, Waleed, Sood, Rapita, Rimon, Gilad, Barki-Harrington, Liza
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2012
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366802/
https://ncbi.nlm.nih.gov/pubmed/22474323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304220
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