Smooth muscle cholesterol enables BK β1 subunit-mediated channel inhibition and subsequent vasoconstriction evoked by alcohol

OBJECTIVE: Hypercholesterolemia and alcohol drinking constitute independent risk factors for cerebrovascular disease. Alcohol constricts cerebral arteries in several species, including humans. This action results from inhibition of voltage- and calcium-gated potassium channels (BK) in vascular smoot...

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Hauptverfasser: Bukiya, Anna N., Vaithianathan, Thirumalini, Kuntamallappanavar, Guruprasad, Asuncion-Chin, Maria, Dopico, Alex M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366592/
https://ncbi.nlm.nih.gov/pubmed/21868700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.233965
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