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Activation of Inhibitors by Sortase Triggers Irreversible Modification of the Active Site()
Sortases anchor surface proteins to the cell wall of Gram-positive pathogens through recognition of specific motif sequences. Loss of sortase leads to large reductions in virulence, which identifies sortase as a target for the development of antibacterials. By screening 135,625 small molecules for i...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3366505/ https://ncbi.nlm.nih.gov/pubmed/17545669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M701857200 |
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