Selective modulation of subtype III IP(3)R by Akt regulates ER Ca(2+) release and apoptosis

Ca(2+) transfer from endoplasmic reticulum (ER) to mitochondria can trigger apoptotic pathways by inducing release of mitochondrial pro-apoptotic factors. Three different types of inositol 1,4,5-trisphosphate receptor (IP(3)R) serve to discharge Ca(2+) from ER, but possess some peculiarities, especi...

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Detalhes bibliográficos
Main Authors: Marchi, S, Marinello, M, Bononi, A, Bonora, M, Giorgi, C, Rimessi, A, Pinton, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366079/
https://ncbi.nlm.nih.gov/pubmed/22552281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.45
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