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Agonist- and Ca(2+)-dependent Desensitization of TRPV1 Channel Targets the Receptor to Lysosomes for Degradation
TRPV1 receptor agonists such as the vanilloid capsaicin and the potent analog resiniferatoxin are well known potent analgesics. Depending on the vanilloid, dose, and administration site, nociceptor refractoriness may last from minutes up to months, suggesting the contribution of different cellular m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365984/ https://ncbi.nlm.nih.gov/pubmed/22493457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289751 |
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