DNA Repair and Replication Fork Helicases Are Differentially Affected by Alkyl Phosphotriester Lesion

DNA helicases are directly responsible for catalytically unwinding duplex DNA in an ATP-dependent and directionally specific manner and play essential roles in cellular nucleic acid metabolism. It has been conventionally thought that DNA helicases are inhibited by bulky covalent DNA adducts in a str...

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Hlavní autoři: Suhasini, Avvaru N., Sommers, Joshua A., Yu, Stephen, Wu, Yuliang, Xu, Ting, Kelman, Zvi, Kaplan, Daniel L., Brosh, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365951/
https://ncbi.nlm.nih.gov/pubmed/22500020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352757
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