Extracellular Signal-regulated Kinase (ERK) Regulates Cortactin Ubiquitination and Degradation in Lung Epithelial Cells

Cortactin, an actin-binding protein, is essential for cell growth and motility. We have shown that cortactin is regulated by reversible phosphorylation, but little is known regarding cortactin protein stability. Here, we show that lipopolysaccharide (LPS)-induced cortactin degradation is mediated by...

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Bibliographic Details
Main Authors: Zhao, Jing, Wei, Jianxin, Mialki, Rachel, Zou, Chunbin, Mallampalli, Rama K., Zhao, Yutong
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365943/
https://ncbi.nlm.nih.gov/pubmed/22514278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339507
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