Serum Calcium-decreasing Factor, Caldecrin, Inhibits Receptor Activator of NF-κB Ligand (RANKL)-mediated Ca(2+) Signaling and Actin Ring Formation in Mature Osteoclasts via Suppression of Src Signaling Pathway

Osteoclasts are essential for bone dynamics and calcium homeostasis. Recently, we reported that serum calcium-decreasing factor, caldecrin, which is a secretory-type serine protease isolated from the pancreas, inhibits osteoclast differentiation by suppression of NFATc1 activity regardless of its ow...

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Hlavní autoři: Tomomura, Mineko, Hasegawa, Hiroya, Suda, Naoto, Sakagami, Hiroshi, Tomomura, Akito
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365728/
https://ncbi.nlm.nih.gov/pubmed/22461633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358796
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