Cisplatin-induced Ototoxicity Is Mediated by Nitroxidative Modification of Cochlear Proteins Characterized by Nitration of Lmo4

Tyrosine nitration is an important sequel of cellular signaling induced by reactive oxygen species. Cisplatin is an anti-neoplastic agent that damages the inner ear through reactive oxygen species and by the formation of DNA adducts. This study reveals a correlation between cisplatin-mediated hearin...

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Autors principals: Jamesdaniel, Samson, Coling, Donald, Hinduja, Sneha, Ding, Dalian, Li, Jun, Cassidy, Linda, Seigel, Gail M., Qu, Jun, Salvi, Richard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365719/
https://ncbi.nlm.nih.gov/pubmed/22493493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.297960
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