Proteomic Analysis of the Balance between Survival and Cell Death Responses in Cisplatin-Mediated Ototoxicity

Cisplatin, a widely used anticancer drug, preferentially damages outer hair cells (OHCs) of the inner ear. In this study, an antibody microarray was used to identify early changes in protein expression in the rat cochlea induced by cisplatin. Only small changes in hearing thresholds (4−34 dB elevati...

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Autori principali: Jamesdaniel, Samson, Ding, Dalian, Kermany, Mohammad Habiby, Davidson, Bruce A., Knight, Paul R., Salvi, Richard, Coling, Donald E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570323/
https://ncbi.nlm.nih.gov/pubmed/18578524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr8002479
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