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Characterization of Chromoshadow Domain-mediated Binding of Heterochromatin Protein 1α (HP1α) to Histone H3

The chromoshadow domain (CSD) of heterochromatin protein 1 (HP1) was recently shown to contribute to chromatin binding and transcriptional regulation through interaction with histone H3. Here, we demonstrate the structural basis of this interaction for the CSD of HP1α. This mode of H3 binding is dep...

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Bibliografiske detaljer
Main Authors: Richart, Alexandria N., Brunner, Clair I. W., Stott, Katherine, Murzina, Natalia V., Thomas, Jean O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365711/
https://ncbi.nlm.nih.gov/pubmed/22493481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337204
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