Neuromedin U Type 1 Receptor Stimulation of A-type K(+) Current Requires the βγ Subunits of G(o) Protein, Protein Kinase A, and Extracellular Signal-regulated Kinase 1/2 (ERK1/2) in Sensory Neurons

Although neuromedin U (NMU) has been implicated in analgesia, the detailed mechanisms still remain unclear. In this study, we identify a novel functional role of NMU type 1 receptor (NMUR1) in regulating the transient outward K(+) currents (I(A)) in small dorsal root ganglion (DRG) neurons. We found...

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Autores principales: Zhang, Yiming, Jiang, Dongsheng, Zhang, Yuan, Jiang, Xinghong, Wang, Fen, Tao, Jin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365707/
https://ncbi.nlm.nih.gov/pubmed/22493291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322271
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