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Neuromedin U Type 1 Receptor Stimulation of A-type K(+) Current Requires the βγ Subunits of G(o) Protein, Protein Kinase A, and Extracellular Signal-regulated Kinase 1/2 (ERK1/2) in Sensory Neurons
Although neuromedin U (NMU) has been implicated in analgesia, the detailed mechanisms still remain unclear. In this study, we identify a novel functional role of NMU type 1 receptor (NMUR1) in regulating the transient outward K(+) currents (I(A)) in small dorsal root ganglion (DRG) neurons. We found...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365707/ https://ncbi.nlm.nih.gov/pubmed/22493291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322271 |
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