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Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines that Clarify Binding Behavior to Model Ligands

Development of a general Ag(I)-promoted reaction for the direct conversion of thioamides to amidines is disclosed. This reaction was employed to prepare a key series of vancomycin aglycon residue 4 substituted amidines that were used to clarify their interaction with model ligands of peptidoglycan p...

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Autors principals: Okano, Akinori, James, Robert C., Pierce, Joshua G., Xie, Jian, Boger, Dale L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365631/
https://ncbi.nlm.nih.gov/pubmed/22568755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302808p
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