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A Shrinkage Approach for Estimating a Treatment Effect Using Intermediate Biomarker Data in Clinical Trials
In clinical trials, a biomarker (S) that is measured after randomization and is strongly associated with the true endpoint (T) can often provide information about T and hence the effect of a treatment (Z) on T. A useful biomarker can be measured earlier than T and cost less than T. In this paper we...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365575/ https://ncbi.nlm.nih.gov/pubmed/21627627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1541-0420.2011.01608.x |
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