Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

The dimerisation of Raf kinases involves a central cluster within the kinase domain, the dimer interface (DIF). Yet, the importance of the DIF for the signalling potential of wild-type B-Raf (B-Raf (wt)) and its oncogenic counterparts remains unknown. Here, we show that the DIF plays a pivotal role...

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Bibliographische Detailangaben
Hauptverfasser: Röring, Michael, Herr, Ricarda, Fiala, Gina J, Heilmann, Katharina, Braun, Sandra, Eisenhardt, Anja E, Halbach, Sebastian, Capper, David, von Deimling, Andreas, Schamel, Wolfgang W, Saunders, Darren N, Brummer, Tilman
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365413/
https://ncbi.nlm.nih.gov/pubmed/22510884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.100
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