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Fe(2+) binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation
Iron increases synthesis rates of proteins encoded in iron-responsive element (IRE)-mRNAs; metabolic iron (“free,” “labile”) is Fe(2+). The noncoding IRE-RNA structure, approximately 30 nt, folds into a stem loop to control synthesis of proteins in iron trafficking, cell cycling, and nervous system...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365203/ https://ncbi.nlm.nih.gov/pubmed/22586079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120045109 |
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