Fe(2+) binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation

Iron increases synthesis rates of proteins encoded in iron-responsive element (IRE)-mRNAs; metabolic iron (“free,” “labile”) is Fe(2+). The noncoding IRE-RNA structure, approximately 30 nt, folds into a stem loop to control synthesis of proteins in iron trafficking, cell cycling, and nervous system...

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Detalhes bibliográficos
Main Authors: Ma, Jia, Haldar, Suranjana, Khan, Mateen A., Sharma, Sohani Das, Merrick, William C., Theil, Elizabeth C., Goss, Dixie J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365203/
https://ncbi.nlm.nih.gov/pubmed/22586079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120045109
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