Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions

Metal ion binding was previously shown to destabilize IRE-RNA/IRP1 equilibria and enhanced IRE-RNA/eIF4F equilibria. In order to understand the relative importance of kinetics and stability, we now report rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with IRP1, and qu...

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Detalhes bibliográficos
Main Authors: Khan, Mateen A., Ma, Jia, Walden, William E., Merrick, William C., Theil, Elizabeth C., Goss, Dixie J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041422/
https://ncbi.nlm.nih.gov/pubmed/24728987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku248
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