Real-time analysis and selection of methylated DNA by fluorescence-activated single molecule sorting in a nanofluidic channel

Epigenetic modifications, such as DNA and histone methylation, are responsible for regulatory pathways that affect disease. Current epigenetic analyses use bisulfite conversion to identify DNA methylation and chromatin immunoprecipitation to collect molecules bearing a specific histone modification....

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Autori principali: Cipriany, Benjamin R., Murphy, Patrick J., Hagarman, James A., Cerf, Aline, Latulippe, David, Levy, Stephen L., Benítez, Jaime J., Tan, Christine P., Topolancik, Juraj, Soloway, Paul D., Craighead, Harold G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365150/
https://ncbi.nlm.nih.gov/pubmed/22586076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117549109
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