Dysregulation of Macrophage-Secreted Cathepsin B Contributes to HIV-1-Linked Neuronal Apoptosis

Chronic HIV infection leads to the development of cognitive impairments, designated as HIV-associated neurocognitive disorders (HAND). The secretion of soluble neurotoxic factors by HIV-infected macrophages plays a central role in the neuronal dysfunction and cell death associated with HAND. One pot...

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Detalhes bibliográficos
Main Authors: Rodriguez-Franco, Eillen J., Cantres-Rosario, Yisel M., Plaud-Valentin, Marines, Romeu, Rafael, Rodríguez, Yolanda, Skolasky, Richard, Meléndez, Viviana, Cadilla, Carmen L., Melendez, Loyda M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365072/
https://ncbi.nlm.nih.gov/pubmed/22693552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036571
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