Tumor Necrosis Factor α Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis

BACKGROUND: Abnormal expression of the liver peptide hormone hepcidin, a key regulator of iron homeostasis, contributes to the pathogenesis of anemia in conditions such as inflammatory bowel disease (IBD). Since little is known about the mechanisms that control hepcidin expression during states of i...

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Main Authors: Shanmugam, Nanda Kumar N., Ellenbogen, Shiri, Trebicka, Estela, Wang, Lijian, Mukhopadhyay, Subhankar, Lacy-Hulbert, Adam, Gallini, Carey Ann, Garrett, Wendy S., Cherayil, Bobby J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365004/
https://ncbi.nlm.nih.gov/pubmed/22675442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038136
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