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Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy “Partial” Substrates for the Biogenic Amine Transporters

Several compounds have been identified that display low-efficacy, “partial substrate” activity. Here, we tested the hypothesis that the mechanism of this effect is a slower rate of induced neurotransmitter efflux than that produced by full substrates. Biogenic amine transporter release assays were c...

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Библиографические подробности
Главные авторы: Rothman, Richard B., Partilla, John S., Baumann, Michael H., Lightfoot-Siordia, Catrissa, Blough, Bruce E.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364510/
https://ncbi.nlm.nih.gov/pubmed/22271821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.188946
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