Germ-line sequence variants of PTEN do not have an important role in hereditary and non-hereditary prostate cancer susceptibility

PTEN (phosphatase and tensin homolog deleted on chromosome 10) functions as a major tumor suppressor gene and is frequently deleted in different types of tumors including prostate cancer (PCa). It was hypothesized that germ-line genetic changes of PTEN affect susceptibility to PCa. Both common (with...

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Hlavní autoři: Xie, Chunmei C, Lu, Lingyi, Sun, Jielin, Zheng, S Lilly, Isaacs, William B, Gronberg, Henrik, Xu, Jianfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364485/
https://ncbi.nlm.nih.gov/pubmed/21633361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jhg.2011.48
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