Aldosterone Inhibits the Fetal Program and Increases Hypertrophy in the Heart of Hypertensive Mice

BACKGROUND: Arterial hypertension (AH) induces cardiac hypertrophy and reactivation of “fetal” gene expression. In rodent heart, alpha-Myosin Heavy Chain (MyHC) and its micro-RNA miR-208a regulate the expression of beta-MyHC and of its intronic miR-208b. However, the role of aldosterone in these pro...

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Main Authors: Azibani, Feriel, Devaux, Yvan, Coutance, Guillaume, Schlossarek, Saskia, Polidano, Evelyne, Fazal, Loubina, Merval, Regine, Carrier, Lucie, Solal, Alain Cohen, Chatziantoniou, Christos, Launay, Jean-Marie, Samuel, Jane-Lise, Delcayre, Claude
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364229/
https://ncbi.nlm.nih.gov/pubmed/22666483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038197
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