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Aldosterone Inhibits the Fetal Program and Increases Hypertrophy in the Heart of Hypertensive Mice
BACKGROUND: Arterial hypertension (AH) induces cardiac hypertrophy and reactivation of “fetal” gene expression. In rodent heart, alpha-Myosin Heavy Chain (MyHC) and its micro-RNA miR-208a regulate the expression of beta-MyHC and of its intronic miR-208b. However, the role of aldosterone in these pro...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364229/ https://ncbi.nlm.nih.gov/pubmed/22666483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038197 |
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