A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting

In yeast, the sorting of transmembrane proteins into the multivesicular body (MVB) internal vesicles requires their ubiquitylation by the ubiquitin ligase Rsp5. This allows their recognition by the ubiquitin-binding domains (UBDs) of several endosomal sorting complex required for transport (ESCRT) s...

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Hauptverfasser: Erpapazoglou, Zoi, Dhaoui, Manel, Pantazopoulou, Marina, Giordano, Francesca, Mari, Muriel, Léon, Sébastien, Raposo, Graça, Reggiori, Fulvio, Haguenauer-Tsapis, Rosine
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364180/
https://ncbi.nlm.nih.gov/pubmed/22493318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-10-0891
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