Liquid chromatographic–electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP(+)) in discrete regions of murine brain

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely used as a neurotoxin in several models of Parkinson’s disease in mice. MPTP is metabolized to 1-methyl-4-phenylpyridinium (MPP(+)), which is a mitochondrial toxicant of central dopamine (DA) neurons. There are species, strain, and age dif...

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Autors principals: Lehner, Andreas, Johnson, Margaret, Simkins, Tyrell, Janis, Kelly, Lookingland, Keith, Goudreau, John, Rumbeiha, Wilson
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363357/
https://ncbi.nlm.nih.gov/pubmed/21142843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15376516.2010.538753
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