Validation and implementation of liquid chromatographic-mass spectrometric (LC-MS) methods for the quantification of tenofovir prodrugs

BACKGROUND: The nucleotide reverse transcriptase inhibitor tenofovir is widely administered in a disoproxil prodrug form (tenofovir disoproxil fumarate) for HIV management and prevention. Recently, novel prodrugs tenofovir alafenamide fumarate (TAF) and hexadecyloxypropyl tenofovir (CMX157) have bee...

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Publicado en:J Pharm Biomed Anal
Main Authors: Hummert, Pamela, Parsons, Teresa L., Ensign, Laura M., Hoang, Thuy, Marzinke, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835418/
https://ncbi.nlm.nih.gov/pubmed/29433097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.02.011
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