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Liquid chromatographic–electrospray mass spectrometric determination of 1-methyl-4-phenylpyridine (MPP(+)) in discrete regions of murine brain
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is widely used as a neurotoxin in several models of Parkinson’s disease in mice. MPTP is metabolized to 1-methyl-4-phenylpyridinium (MPP(+)), which is a mitochondrial toxicant of central dopamine (DA) neurons. There are species, strain, and age dif...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3363357/ https://ncbi.nlm.nih.gov/pubmed/21142843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15376516.2010.538753 |
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