Regulation of Physiologic Actions of LRRK2: Focus on Autophagy

BACKGROUND: Mutations in LRRK2 are associated with familial and sporadic Parkinson's disease (PD). Subjects with PD caused by LRRK2 mutations show pleiotropic pathology that can involve inclusions containing α-synuclein, tau or neither protein. The mechanisms by which mutations in LRRK2 lead to...

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Main Authors: Ferree, Andrew, Guillily, Maria, Li, Hu, Smith, Katelyn, Takashima, Aki, Squillace, Rachel, Weigele, Manfred, Collins, James J., Wolozin, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado: S. Karger AG 2012
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Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363354/
https://ncbi.nlm.nih.gov/pubmed/22204929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000332599
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