APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer's Disease Transgenics

BACKGROUND: After age, the second largest risk factor for Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype, where APOE4 is associated with lower apoE protein levels, more severer brain pathology, enhanced inflammation and disease. Small peptides corresponding to the receptor-binding...

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Autors principals: Vitek, M.P., Christensen, D.J., Wilcock, D., Davis, J., Van Nostrand, W.E., Li, F.Q., Colton, C.A.
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2012
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Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363346/
https://ncbi.nlm.nih.gov/pubmed/22326991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000334914
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