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Receptor Conformations Involved in Dopamine D(2L) Receptor Functional Selectivity Induced by Selected Transmembrane-5 Serine Mutations
Although functional selectivity is now widely accepted, the molecular basis is poorly understood. We have studied how aspects of transmembrane region 5 (TM5) of the dopamine D(2L) receptor interacts with three rationally selected rigid ligands (dihydrexidine, dinapsoline, and dinoxyline) and the ref...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362898/ https://ncbi.nlm.nih.gov/pubmed/22416052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.075457 |
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