Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response

We report the first observation that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) can decrease when a central nervous system drug acts as an intracellular pharmacological chaperone for its classic receptor. Transient expression of α4β2 nicotinic receptors (nAChRs) in Neu...

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Bibliographic Details
Main Authors: Srinivasan, Rahul, Richards, Christopher I., Xiao, Cheng, Rhee, Doreen, Pantoja, Rigo, Dougherty, Dennis A., Miwa, Julie M., Lester, Henry A.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362896/
https://ncbi.nlm.nih.gov/pubmed/22379121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.077792
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