Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth

Proliferating cell nuclear antigen (PCNA), a potential anticancer target, forms a homotrimer and is required for DNA replication and numerous other cellular processes. The purpose of this study was to identify novel small molecules that modulate PCNA activity to affect tumor cell proliferation. An i...

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Main Authors: Tan, Zongqing, Wortman, Matthew, Dillehay, Kelsey L., Seibel, William L., Evelyn, Chris R., Smith, Shanna J., Malkas, Linda H., Zheng, Yi, Lu, Shan, Dong, Zhongyun
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362894/
https://ncbi.nlm.nih.gov/pubmed/22399488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.077735
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