Synthesis and SAR of selective small molecule Neuropeptide Y Y2 receptor antagonists

Highly potent and selective small molecule Neuropeptide Y Y2 receptor antagonists are reported. The systematic SAR exploration of a hit molecule N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide, identified from HTS, led to the discovery of highly potent NPY Y2 antagonists 16...

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Autors principals: Mittapalli, Gopi Kumar, Vellucci, Danielle, Yang, Jun, Toussaint, Marion, Brothers, Shaun P, Wahlestedt, Claes, Roberts, Edward
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362798/
https://ncbi.nlm.nih.gov/pubmed/22607676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.107
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