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Selective and Brain Penetrant Neuropeptide Y Y2 Receptor Antagonists Discovered by Whole-Cell High-Throughput Screening

The role of neuropeptide Y Y2 receptor (Y2R) in human diseases such as obesity, mood disorders, and alcoholism could be better resolved by the use of small-molecule chemical probes that are substantially different from the currently available Y2R antagonist, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[...

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Detalhes bibliográficos
Main Authors: Brothers, Shaun P., Saldanha, S. Adrian, Spicer, Timothy P., Cameron, Michael, Mercer, Becky A., Chase, Peter, McDonald, Patricia, Wahlestedt, Claes, Hodder, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802430/
https://ncbi.nlm.nih.gov/pubmed/19837904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.058677
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