An open-label, phase 1 study evaluating safety, tolerability, and pharmacokinetics of linifanib (ABT-869) in Japanese patients with solid tumors

PURPOSE: This phase 1 study assessed the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of linifanib in Japanese patients with advanced solid tumors. METHODS: Patients were assigned to one of four sequential cohorts (0.05, 0.10, 0.20, or 0.25 mg/kg) of oral, once-daily li...

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Main Authors: Asahina, Hajime, Tamura, Yosuke, Nokihara, Hiroshi, Yamamoto, Noboru, Seki, Yoshitaka, Shibata, Takashi, Goto, Yasushi, Tanioka, Maki, Yamada, Yasuhide, Coates, Andrew, Chiu, Yi-Lin, Li, Xiaohui, Pradhan, Rajendra, Ansell, Peter J., McKeegan, Evelyn M., McKee, Mark D., Carlson, Dawn M., Tamura, Tomohide
Formato: Artigo
Idioma:Inglês
Publicado: Springer-Verlag 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362725/
https://ncbi.nlm.nih.gov/pubmed/22382879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1846-6
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