A Model of DENV-3 Infection That Recapitulates Severe Disease and Highlights the Importance of IFN-γ in Host Resistance to Infection

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was prece...

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Main Authors: Costa, Vivian V., Fagundes, Caio T., Valadão, Deborah F., Cisalpino, Daniel, Dias, Ana Carolina F., Silveira, Kátia D., Kangussu, Lucas M., Ávila, Thiago V., Bonfim, Maria Rosa Q., Bonaventura, Daniela, Silva, Tarcília A., Sousa, Lirlândia P., Rachid, Milene A., Vieira, Leda Q., Menezes, Gustavo B., de Paula, Ana Maria, Atrasheuskaya, Alena, Ignatyev, George, Teixeira, Mauro M., Souza, Danielle G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362616/
https://ncbi.nlm.nih.gov/pubmed/22666512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001663
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