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Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease
Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A(2A) receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice an...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3362368/ https://ncbi.nlm.nih.gov/pubmed/22262774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-375899 |
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