Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease

Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A(2A) receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice an...

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Detaylı Bibliyografya
Asıl Yazarlar: Tsukamoto, Hiroki, Chernogorova, Petya, Ayata, Korcan, Gerlach, Ulrike V., Rughani, Ankur, Ritchey, Jerry W., Ganesan, Jayanthi, Follo, Marie, Zeiser, Robert, Thompson, Linda F., Idzko, Marco
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2012
Konular:
Transplantation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362368/
https://ncbi.nlm.nih.gov/pubmed/22262774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-375899
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