Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease

Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A(2A) receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice an...

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Autores principales: Tsukamoto, Hiroki, Chernogorova, Petya, Ayata, Korcan, Gerlach, Ulrike V., Rughani, Ankur, Ritchey, Jerry W., Ganesan, Jayanthi, Follo, Marie, Zeiser, Robert, Thompson, Linda F., Idzko, Marco
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362368/
https://ncbi.nlm.nih.gov/pubmed/22262774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-375899
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