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Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease

Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A(2A) receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice an...

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מידע ביבליוגרפי
Main Authors: Tsukamoto, Hiroki, Chernogorova, Petya, Ayata, Korcan, Gerlach, Ulrike V., Rughani, Ankur, Ritchey, Jerry W., Ganesan, Jayanthi, Follo, Marie, Zeiser, Robert, Thompson, Linda F., Idzko, Marco
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Hematology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362368/
https://ncbi.nlm.nih.gov/pubmed/22262774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-375899
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