Incorporation and Controlled Release of Silyl Ether Prodrugs from PRINT Nanoparticles

Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm x 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water soluble drug within a hydrogel. The resulting drug...

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Bibliografiske detaljer
Main Authors: Parrott, Matthew C., Finniss, Mathew, Luft, J. Chris, Pandya, Ashish, Gullapalli, Anuradha, Napier, Mary E., DeSimone, Joseph M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362319/
https://ncbi.nlm.nih.gov/pubmed/22545784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja301710z
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