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Sphingomyelinase depresses force and calcium sensitivity of the contractile apparatus in mouse diaphragm muscle fibers

Diseases that result in muscle weakness, e.g., heart failure, are characterized by elevated sphingomyelinase (SMase) activity. In intact muscle, SMase increases oxidants that contribute to diminished muscle force. However, the source of oxidants, specific processes of muscle contraction that are dys...

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Bibliografski detalji
Glavni autori: Ferreira, Leonardo F., Moylan, Jennifer S., Stasko, Shawn, Smith, Jeffrey D., Campbell, Kenneth S., Reid, Michael B.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362233/
https://ncbi.nlm.nih.gov/pubmed/22362402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01269.2011
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