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TNF signals via neuronal-type nitric oxide synthase and reactive oxygen species to depress specific force of skeletal muscle

TNF promotes skeletal muscle weakness, in part, by depressing specific force of muscle fibers. This is a rapid, receptor-mediated response, in which TNF stimulates cellular oxidant production, causing myofilament dysfunction. The oxidants appear to include nitric oxide (NO); otherwise, the redox mec...

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Detalhes bibliográficos
Main Authors: Stasko, Shawn A., Hardin, Brian J., Smith, Jeffrey D., Moylan, Jennifer S., Reid, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680824/
https://ncbi.nlm.nih.gov/pubmed/23558387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00871.2012
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