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TNF signals via neuronal-type nitric oxide synthase and reactive oxygen species to depress specific force of skeletal muscle
TNF promotes skeletal muscle weakness, in part, by depressing specific force of muscle fibers. This is a rapid, receptor-mediated response, in which TNF stimulates cellular oxidant production, causing myofilament dysfunction. The oxidants appear to include nitric oxide (NO); otherwise, the redox mec...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3680824/ https://ncbi.nlm.nih.gov/pubmed/23558387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00871.2012 |
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