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Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres

Studies on intact muscle fibres indicate that reactive oxygen species (ROS) produced during muscle activity, or applied exogenously, can cause decreased force responses primarily by reducing the Ca(2+) sensitivity of the contractile apparatus. Identification of the molecular basis of this effect is...

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Main Authors: Murphy, R M, Dutka, T L, Lamb, G D
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2465198/
https://ncbi.nlm.nih.gov/pubmed/18308823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.150516
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